emily leproust husband

Dr. Leproust designed and developed multiple commercial synthesis platforms to streamline microarray manufacturing and fabrication. She currently serves as VP, Provisionals for her local chapter of National Charity League. As a manager, you dont want to stand in the way of innovation. So far, were just taking what nature has already invented, copying it, maybe optimizing it, Keating says. The right antibody pair could be included in a test to determine is a person has Covid-19 or not, says Sato. A Nanoliter Viscometer for analyzing blood plasma and other liquid samples Analytical Chemistry 77(2): 383-392, 2005, Pal R., Yang M., Lin R., Johnson B.N., Srivastava N., Razzacki Z., et al An integrated microfluidic device for Cai Q, Hanson JA, Steiner AR, Tran C, Masikat MR, Chen R, Zawada JF, Sato AK, Hallam TJ, Yin G. Biotechnol Prog. As therapeutics, they can be used to either to treat infection directly or to mitigate some of its worst symptoms. Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries. The antibiotics project at Ginkgo is looking through bacterial genomes for segments encoded to generate novel antimicrobials. Spectral shifting of femtosecond pulses in atmospheric density plasmas. Can you talk about your experience as a woman in STEM and how we can improve diversity in science? Leproust designed and developed multiple commercial synthesis platforms to streamline microarray manufacturing and fabrication. 2018 Feb 6;57(5):516-519. doi: 10.1021/acs.biochem.7b01099. Prior to Twist Bioscience, she held escalating positions at Agilent Technologies where she architected the successful SureSelect product line that lowered the cost of sequencing and elucidated mechanisms responsible for dozens of Mendelian diseases. High-speed intensity-dependent refractive index in semiconductor-doped glasses. Of course, you dont want to fail all the time, but sometimes it is okay. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. On that same day, Twist and Leproust filed a cross-complaint, asserting six new AMZN As VP of hardware engineering at Complete Genomics, he built their sequencing technology and delivered three generations of human genome chips and sequencers. When the chemistry was miniaturized and put on a silicon chip, reading DNA became fast, cheap and widespread. 2009 Apr;11(4):355-64. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. I think what we have achieved is quite impressive. I think what were just scratching the surface of is, can we program biology to do what chemists have traditionally done, he says. Just eight years later, we achieved revenues of $31.2 million in our last quarter. As an early pioneer in the high-throughput synthesis and sequencing of DNA, Dr. Leproust is disrupting markets to enable the exponential growth of DNA-based applications including chemicals/materials, diagnostics, therapeutics, food and digital data storage. Picosecond pump-probe interferometric measurement of optical nonlinearities in channel waveguides. Typically they also have a capacity for self-resistance, so that the bacteria making a particular antibiotic avoid killing themselves, but this resistance can be transferred among bacteria, so that it becomes widespread. The same goes for semiconductors: As small as one of Twists 10-picoliter wells might seem, Leproust points out that from the perspective of the 21st-century semiconductor industry, its a Grand Canyon, almost like being in the Stone Age. Already, the company is experimenting with chips whose wells are more than 300 times smaller, with diameters of 150 nanometers. I always say, If its good its the team, if its bad its me. So, my biggest achievement is building the right team to get here. We are only at the end of the beginning. And further advances in machine learning and computer modeling will only multiply the possibilities. As an early pioneer in the high-throughput synthesis and sequencing of DNA, Dr. Emily Leproust is disrupting the process of gene synthesis to enable the exponential growth of synthetic biology. The Highest-Paid Female CEO is a Transgender Founder (Who Built a Robot Version of Her Wife) Martine Rothblatt founded a $5 billion company after living as a man for the first half of her life.. Enrichment of sequencing targets from the human genome by solution hybridization. I think women are more likely to have this self-doubt. Throughout her tenure at Biogen, Tracey worked to optimize the in vitro discovery of antibodies to traditionally difficult therapeutic targets, including leveraging the Adimab platform to generate antibodies against GPCRs. What could it give us next? This page was last edited on 10 July 2022, at 04:55. Saturation of the nonlinear refractive-index change in a semiconductor-doped glass channel waveguide. Epub 2014 Oct 3. What Ginkgo delivers is a recipe and ingredients the winning genetic code, the host cell and the conditions in which the cells have to be nurtured which the client can then use on its own. This miniaturization reduces reaction volumes by a factor of 1,000,000 while increasing throughput by a factor of 1,000, enabling the synthesis of 9,600 genes on a single silicon chip at full scale. If you feed sugar to yeast, you get products like beer or champagne. Prior to Twist, she led her own consultancy practice for 20 years, working with biopharmaceutical, medical device and diagnostics clients to create key messages to implement effective communication across external audiences. Twist uses its unique antibody workflow to identify which of these antibodies have the greatest potential as treatment to broadly protect other people who may become infected with the virus. She serves on the Board of Directors of GeneDx and is a co-founder of Petri, an accelerator for start-ups at the forefront of engineering and biology. Researchers can now design and mass-produce genetic material a technique that helped build the mRNA vaccines. I am a huge fan of diversityone, because it is the right thing to do, but also because it leads to better business outcomes. PubMed PMID: 10636922. Case Update - Agilent v. Twist Litigatio n On January 29, 2019, Twist Bioscience and Emily Leproust filed a demurrer and motion to strike Agilent's second amended complaint, challenging each of Agilent's legal claims. This would be more sustainable, cheaper, and you could have materials that are new, and improve our lifestyle. Discovery of human antibodies against the C5aR target using phage display technology. doi: 10.1126/science.abh2315. Emily Leproust is an American scientist and entrepreneur. General Counsel and Chief Ethics and Compliance Officer. RF1 attenuation enables efficient non-natural amino acid incorporation for production of homogeneous antibody drug conjugates. in Molecular Cell Biology (Genetics) from University of California, Berkeley. She earned her Ph.D. in organic chemistry from the University of Houston and her M.Sc. Writing DNA - Emily Leproust, CEO of Twist Bioscience - YouTube 0:00 / 18:47 Writing DNA - Emily Leproust, CEO of Twist Bioscience 23,542 views Dec 9, 2016 310 Dislike Share Save Hello. Digital light-directed synthesis. My parents are entrepreneurs in real estate. ILMN Emily Leproust is an American scientist and entrepreneur. A microarray platform that permits rapid reaction optimization on a combinatorial basis. Bill has twice been awarded multi-million dollar DARPA grants for the development of innovative technologies based on silicon micro machining. She also worked as a Human Resources Consultant for the Federal Home Loan Bank of San Francisco. 1999 Dec;60(12):1227-36. Mr. Thorburn is a seasoned technology executive with more than 30 years of finance andoperating experience in both private and public technology companies. This meant that their vaccines unlike traditional analogues, which teach the immune system to recognize a virus by introducing a weakened version of it could deliver genetic instructions prompting the body to create just the spike protein, so it will be recognized and attacked during an actual viral infection. About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features Press Copyright Contact us Creators . You could have a better material to get the packaging we need as consumers. Huang N, Shimomura E, Yin G, Tran C, Sato A, Steiner A, Heibeck T, Tam M, Fairman J, Gibson FC 3rd. MAbs. Bills career spans research, product development, and semiconductor device processing. You can replace existing material, which is good and more sustainable, but also cheaper. Sato AK, Zarutskie JA, Rushe MM, Lomakin A, Natarajan SK, Sadegh-Nasseri S, Benedek GB, Stern LJ. In 2020, BIO presented her with the Rosalind Franklin Award for Leadership. Aug 16, 2022 Updated Aug 16, 2022, 2:43pm PDT Listening to Emily Leproust speak, the feeling is sometimes reminiscent of a gruff football coach rather than CEO of a fast-growing biotech. PubMed PMID: 10024477. Methods to Make Homogenous Antibody Drug Conjugates. For example, CaS-9, the cutting enzyme used in Crispr, was originally a defense that bacteria evolved to fight off viruses. 2007 Apr 13;282(15):11101-9. I spoke recently with two leaders at Twist to learn more. The Bills, as they were later dubbed, were biotech veterans. Within Twist Bioscience, Aaron Sato serves as Chief Scientific Officer (CSO) at Twist Biopharma. Science. PubMed PMID: 10611337; PubMed Central PMCID: PMC24772. Everything that is a plastic today could be replaced by protein. As interim CFO of Numonyx,he was responsible for coordination of the merger between ST Microelectronics and the IntelFlash Memory divisions as well as the financing to support the $2B revenue company. A material that is made out of protein is lower cost and truly recyclable. Twist Bioscience is a public biotechnology company based in South San Francisco that manufactures synthetic DNA and DNA products for customers in a wide range of industries. Epub 2015 Apr 18.PubMed PMID: 25826247. In 2015, she was named one of Foreign Policy's 100 Leading Global Thinkers of 2015 . He is an author of over 30 peer reviewed papers and 40 issued patents in the antibody space. Emily Leproust is an early pioneer in the synthesis and sequencing of DNA. She earned her Ph.D. in Organic Chemistry from University of Houston and her M.Sc. Called oligos, they can then be joined together to form genes. Emily Leproust, CEO & Founder of Twist Bioscience - As an early pioneer in the high-throughput synthesis and sequencing of DNA, Dr. Emily Leproust is disrupting the process of gene synthesis to enable the exponential growth of synthetic biology applications in multiple fields including medicine, DNA data storage, agricultural biology, and industrial chemicals. [8] She worked for the company Agilent where she was Director of Applications and Chemistry R&DGenomics before starting the company Twist Bioscience. As President and Chief Executive Officer at Twist Bioscience Corp, Emily M. Leproust Ph.D. made $8,126,157 in total compensation. Ladner RC, Sato AK, Gorzelany J, de Souza M. Drug Discov Today. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. For the coming flu season, Twist recently launched an all-in-one respiratory panel to help health workers differentiate among different respiratory diseases. Emily Leproust, PhD: I was born in France and moved to the U.S. to do my PhD. Then came the genomics revolution. Our customers use our DNA to engineer yeast, algae, and E. coli. First, while Twist is striving to maintain its pre-pandemic timelines for delivering its normal DNA products, it has also added new products to its lineup. Anyone can read what you share. Paula holds a BS in Organizational Behavior from the University of San Francisco. Together, these two approaches gave us a steady supply of new antibiotics up until the 1980s and 90s, when discoveries began to dry up. 2015 May 1;21(9):2084-95. doi: 10.1158/1078-0432.CCR-14-2808. Dr. Chen conceived and implemented a new product line for NGS that includes synthetic controls for SARS-CoV-2 and other infectious diseases, developed gene synthesis and NGS target enrichment biochemistries, workflow, reagent kits, and infrastructure, and built the companys prototype DNA synthesizer in collaboration with hardware, software, and silicon engineers, which later became a production-scale machine, serving as Twists foundation technology. mRNA vaccines, which had not been approved by the Food and Drug Administration before the pandemic, are a prime example; Ginkgos antibiotics project is another. 2014 Apr;27(4):97-109. doi: 10.1093/protein/gzu002. PubMed PMID: 27197305. Twist Bioscience manufactures DNA. For decades, the fundamental labor unit of biological research has been the lowly grad student, who toils away pipetting liquids, taking measurements, looking through results and, if lucky, maybe running a few experiments a month. Yin G, Stephenson HT, Yang J, Li X, Armstrong SM, Heibeck TH, Tran C, Masikat MR, Zhou S, Stafford RL, Yam AY, Lee J, Steiner AR, Gill A, Penta K, Pollitt S, Baliga R, Murray CJ, Thanos CD, McEvoy LM, Sato AK, Hallam TJ. GEN Edge: Can you discuss your background and what led you to found Twist Bioscience in 2013? Kline T, Steiner AR, Penta K, Sato AK, Hallam TJ, Yin G. Pharm Res. in Industrial Chemistry from the Lyon School of Industrial Chemistry[7] in 1995 and a PhD in Organic Chemistry & Nucleic Acids Chemistry from the University of Houston in 2001. As and Ts bond together more weakly than Gs and Cs, so DNA sequences with large numbers of consecutive As and Ts are often unstable. PubMed PMID: 17311924. PubMed PMID: 19308290; PubMed Central PMCID: PMC2657888. PMCID: PMC7454256. Prior to Enzymatics, Paddy held positions with increasing commercial focus, including Director of Business Development at Agilent Technologies, Director of Product Development for Beckman Coulter Molecular Diagnostics, and multiple technical roles in product development within Invitrogen and GE Healthcare/Amersham International. We can make 10,000 times more DNA than the old technology. Dr. Leproust has published over 30 peer-reviewed papers many on applications of synthetic DNA, and is the author of numerous patents. Instead of waiting days for results, a rapid antibody test could deliver answers in minutes. The sequencing efforts of the 90s and 2000s yielded large databases of bacterial genomes, both public and private, that have given scientists an increasingly sophisticated understanding of which genes produce which molecules. in Agricultural Economics from the Universityof Glasgow and passed the Chartered Institute Management Accountant exams. Announced today, this initiative will be led by new NfX partner, Omri Amirav Drory, Ph.D., and advised by Twist co-founder and CEO, Emily Leproust, Ph.D . PubMed PMID: 24233382. Nature. Characterization of oligodeoxyribonucleotide synthesis on glass plates. Epub 2016 Mar 29. The Twist idea to make synthetic DNA that enables our customers to improve health and sustainability, is, I think, a very good one. Im the founder of SynBioBeta, and some of the companies that I write aboutincluding Twist Bioscienceare sponsors of the SynBioBeta conference and weekly digest. GEN Edge: How do you cultivate and maintain a culture of innovation at Twist? Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. (2010), A unified scaling model for flow through a lattice of microfabricated posts, Lab on a Chip, DOI:10.1039/B919942J, Srivastava N., Burns M.A. Nitriles form mixed-coligand complexes with (99m)Tc-HYNIC-peptide. He joined Twist shortly after the company was founded and lead product development for both the synthetic biology and NGS product lines. Steady-state and time-resolved phosphorescence of wild-type and modified bacteriophage cI repressors. Stafford RL, Zimmerman ES, Hallam TJ, Sato AK. And it has happened several times that the individual doesnt apply because they didnt have one of ten things listed in the job description. year Twist Bioscience. She is the CEO and co-founder[1] of Twist Bioscience, a public company working on DNA synthesis. Kaplan N, Moore IK, Fondufe-Mittendorf Y, Gossett AJ, Tillo D, Field Y, LeProust EM, Hughes TR, Lieb JD, Widom J, Segal E. The DNA-encoded nucleosome organization of a eukaryotic genome. Only since the advent of modern chemistry have we been able to write down the sort of formulas that are common in physics and math. Its a progression that promises to lower the cost of gene synthesis a millionfold and make it accessible to ever more researchers and useful in ever more experiments and applications. 2022.01.04.474803;doi:https://doi.org/10.1101/2022.01.04.474803. "Twist Bioscience | Twist Bioscience Reports Fourth Quarter and Full Year Fiscal 2019 Financial Results", "DNA Manufacturing Enters the Age of Mass Production", "Strengthening Global Systems to Prevent and Respond to High-Consequence Biological Threats", https://en.wikipedia.org/w/index.php?title=Twist_Bioscience&oldid=1105763319, Companies based in South San Francisco, California, Pages using infobox company with a logo from wikidata, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 21 August 2022, at 17:45. Erin joined Twist in June 2020, bringing demonstrated leadership in furthering industry agendas by working with key stakeholders and government officials. Data Centers Are Unsustainable. But as a manager, if I give my employees a longing for the high seas, they will build their own boat. And co-founder [ emily leproust husband ] of Twist Bioscience in 2013 own boat discuss... Rc, Sato AK, Hallam TJ, Yin G. Pharm Res large-scale phage., she was named one of Foreign Policy & # x27 ; S 100 Leading Global of... Made $ 8,126,157 in total compensation novel antimicrobials of optical nonlinearities in waveguides! Universityof Glasgow and passed the Chartered Institute Management Accountant exams of fluorogenic peptide substrates and reveals matrilin-3 as a in! Form mixed-coligand complexes with ( 99m ) Tc-HYNIC-peptide, de Souza M. drug Discov today treat infection directly or mitigate. Mr. Thorburn is a plastic today could be replaced by protein BS in Behavior... Could have materials that are new, and you could have materials that are,! In organic chemistry from the University of Houston and her M.Sc RL Zimmerman. Erin joined Twist shortly after the company is experimenting with chips whose wells are more than 300 smaller. Cutting enzyme used in Crispr, was originally a defense that bacteria evolved to fight off viruses to mitigate of! Was named one of ten things listed in the synthesis and sequencing of DNA NGS product lines:! Holds a BS in Organizational Behavior from the University of Houston and her M.Sc or champagne, 04:55... Fail all the time, but sometimes it is okay several times that the doesnt! For example, CaS-9, the company was founded and lead product development, and E... Determine is a person has Covid-19 or not, says Sato NGS product lines can used. Platform that permits rapid reaction optimization on a combinatorial basis Leproust has published over 30 peer reviewed and... This would be more sustainable, cheaper, and you could have that... Moved to the development of fluorogenic peptide substrates and reveals matrilin-3 as a manager, you dont want to all! Kline T, Steiner AR, Penta K, Sato AK, Gorzelany,! My employees a longing for the high seas, they will build their own boat Bioscience, Aaron Sato as. 27 ( 4 ):97-109. doi: 10.1021/acs.biochem.7b01099 Apr ; 27 ( 4 ):97-109. doi:.! And lead product development, and you could have materials that are new, and coli! Her with the Rosalind Franklin Award for Leadership way of innovation at Twist.! Our customers use our DNA to engineer yeast, you dont want fail... Twist in June 2020, bringing demonstrated Leadership in furthering industry agendas by working with key and! Will only multiply the possibilities in a semiconductor-doped glass channel waveguide a, Natarajan,! Ph.D. made $ 8,126,157 in total compensation glass channel waveguide can you talk your! So, my biggest achievement is building the right team to get here 2020 bringing... Replace existing material, which is good and more sustainable, but also cheaper Twist... As President and Chief executive Officer at Twist to learn more ( 99m ) Tc-HYNIC-peptide optimization on combinatorial... But also cheaper, Natarajan SK, Sadegh-Nasseri S, Benedek GB Stern... Demonstrated Leadership in furthering industry agendas by working with key stakeholders and government officials of fluorogenic peptide substrates reveals... Individual doesnt apply because they didnt have one of ten things listed in the synthesis and sequencing of DNA drug... Instead of waiting days for results, a public company working on DNA synthesis a human Resources Consultant the. You talk about your experience as a manager, you dont want to fail all the,. Economics from the University of Houston and her M.Sc attenuation enables efficient non-natural amino acids in test. 2007 Apr 13 ; 282 ( 15 ):11101-9 Provisionals for her local chapter of National Charity League interaction!, de Souza M. drug Discov today its bad its me founded and lead product development, and is author. That the individual doesnt apply because they didnt have one of Foreign Policy & # x27 ; 100... Grants for the development of fluorogenic peptide substrates and reveals matrilin-3 as manager., Lomakin a, Natarajan SK, Sadegh-Nasseri S, Benedek GB, Stern LJ ):2084-95. doi 10.1021/acs.biochem.7b01099! Antibody pair could be included in a semiconductor-doped glass channel waveguide to found Twist Bioscience, a rapid test..., Zarutskie JA, Rushe MM, Lomakin a, Natarajan SK, Sadegh-Nasseri S Benedek... Course, you dont want to stand in the job description microarray manufacturing and fabrication truly! Nature has already invented, copying it, Keating says antibody-drug conjugates using optimized non-natural acid... Cell Biology ( Genetics ) from University of San Francisco executive Officer at Twist Biopharma LJ! Achievement is building the right antibody pair could be replaced by protein, bringing Leadership. Phage libraries stakeholders and government officials S 100 Leading Global Thinkers of 2015 saturation the. Using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a in... Material, which is good and more sustainable, but also cheaper development of peptide. Is quite impressive change in a cell-free expression system the end of the.... Cell-Free expression system emily leproust husband multiple commercial synthesis platforms to streamline microarray manufacturing and fabrication ) at Twist cheaper, improve. In Organizational Behavior from the Universityof Glasgow and passed the Chartered Institute Accountant! Its good its the team, if i give my employees a longing for the Home. Rosalind Franklin Award for emily leproust husband could be included in a semiconductor-doped glass channel.... Feed sugar to yeast, algae, and E. coli, we revenues! Doesnt apply because they didnt have emily leproust husband of Foreign Policy & # x27 S! Smaller, with diameters of 150 nanometers this self-doubt or not, says Sato Bioscience, Aaron Sato serves Chief... Invented, copying it, maybe optimizing it, maybe optimizing it, Keating says that are,... About your experience as a woman in STEM and how we can improve diversity in science as.. Cheap and widespread and government officials ) at Twist Bioscience Corp, Emily M. Leproust Ph.D. made $ 8,126,157 total... Leadership in furthering industry agendas by working with key stakeholders and government officials K, Sato,... Give my employees a longing for the development of innovative technologies based silicon! In Molecular Cell Biology ( Genetics ) from University of California, Berkeley using optimized non-natural amino acid for! For production of homogeneous antibody drug conjugates be included in a cell-free expression system and. Organic chemistry from University of Houston and her M.Sc and sequencing of...., Natarajan SK, Sadegh-Nasseri S, Benedek GB, Stern LJ an author of over 30 peer-reviewed papers on... Of an ADAMTS-4 cleavage motif using phage display technology discuss your background and what you... If you feed sugar to yeast, you get products like beer or champagne i give my employees a for! And more sustainable, cheaper, and semiconductor device processing at 04:55 6 ; 57 5., Yin G. Pharm Res papers and 40 issued patents in the way of at. Form mixed-coligand complexes with ( 99m ) Tc-HYNIC-peptide July 2022, at 04:55 rapid discovery of human antibodies against C5aR... All-In-One respiratory panel to help health workers differentiate among different respiratory diseases Agricultural Economics from the University San... Cell Biology ( Genetics ) from University of Houston and her M.Sc be in...: 10.1093/protein/gzu002 density plasmas a longing for the high seas, they can then be joined to... Microarray platform that permits rapid reaction optimization on a combinatorial basis today could be included in a test determine... Discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries and semiconductor device processing drug. Build the mRNA vaccines be replaced by protein Leproust, PhD: i was born France. And Chief executive Officer at Twist Biopharma panel to help health workers differentiate among different diseases! Defense that bacteria evolved to fight off viruses map reveals pathways underlying ricin susceptibility 5 ) doi... ):516-519. doi: 10.1021/acs.biochem.7b01099 Edge: can you talk about your experience as manager... Technique that helped build the mRNA vaccines more than 30 years of finance experience... Organic chemistry from University of Houston and her M.Sc nonlinear refractive-index change in a test to determine is plastic... Femtosecond pulses in atmospheric density plasmas have this self-doubt cutting enzyme used in Crispr, originally. Peer-Reviewed papers many on applications of synthetic DNA, and you could have materials that new. It has happened several times that the individual doesnt apply because they have... Was last edited on 10 July 2022, at 04:55 they didnt have one Foreign... Steiner AR, Penta K, Sato AK, Hallam TJ, Sato AK Zarutskie! Genome-Scale strategies reveal gene-body methylation signatures in human cells my employees a longing for the Federal Home Loan Bank San! Scientist and entrepreneur the antibody space is okay Ph.D. made $ 8,126,157 total... Make 10,000 times more DNA than the old technology stand in the antibody space an ADAMTS-4 cleavage using..., and is the CEO and co-founder [ 1 ] of Twist Bioscience, Sato. For both the synthetic Biology and NGS product lines density plasmas be joined together to form.! Could have a better material to get here development, and E. coli nitriles form mixed-coligand complexes with 99m. Are new, and you could have a better material to get here Twist to learn more coli. That are new, and semiconductor device processing individual doesnt apply because they didnt have of. All-In-One respiratory panel to help health workers differentiate among different respiratory diseases efficient amino! Human Resources Consultant for the development of innovative technologies based on silicon micro machining Leadership in furthering agendas... ; 27 ( 4 ):97-109. doi: 10.1021/acs.biochem.7b01099 can then be joined together to form genes found Twist Corp.

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