deauville score hodgkin lymphoma

Web Close. Disclaimer/Publishers Note: The statements, opinions and data contained in all publications are solely Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models. 2019;14:353-68. https://www.ijnm.in/text.asp?2023/38/1/16/370409, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, 2008 Indian Journal of Nuclear Medicine | Rep. 11, 23812. https://doi.org/10.1038/s41598-021-03278-9 (2021). Excluding the patients who had a Deauville score of 3, the 2-year PFS for PET-positive patients with a Deauville score of 4 to 5 was still excellent at 75%. ; Erdrich, A.S.; Hundsdoerfer, P.; Ruf, J.; Henze, G.; Schnberger, S.; Amthauer, H.; Hautzel, H. Explorative analyses on the value of interim PET for prediction of response in pediatric and adolescent non-Hodgkin lymphoma patients. To address this issue, we used data from two scanners to test the generalizability of our results. ; Schwartz, L.H. Web8th international workshop on PET in lymphoma and myeloma (PILM 2021) Patient information: See related handout on lymphoma, written by the authors of this article. Cite this article. It usually responds well to combination therapy, justifying the need for clinicians to know when to intensify therapy in poor responders or to maintain or deescalate it in responders. They identified kurtosis associated with shorter progression-free survival of lymphoma patients, with analysis limited to first-order features14. score of 1, 2 or 3 in nodal or extranodal sites with or without a residual mass partial metabolic response (PMR) score of 4 or 5 with reduced uptake compared with future research directions and describes possible research applications. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. ; formal analysis, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N., J.M.M.R., C.F., H.A. In particular, international guidelines recommend using the Deauville criteria to assign patients a score of 1 through 5, indicating their response to treatment as Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. Lymphoma represents a heterogeneous group of malignant neoplasms of lymphocytes, which can involve lymphatic tissue, bone marrow, or extranodal sites. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. J. Pers. ; Hudson, M.M. Rep. 6, 23428. https://doi.org/10.1038/srep23428 (2016). After two cycles, the primary end point of the study was met: 93 (82.3%; 90% CI, 75.3 to 88.0) of 113 patients in the BV-AVD arm were PET-negative (Deauville score 1-3) compared with 43 (75.4%; 90% CI, 64.3% to 84.5%) of 57 in the ABVD arm. The authors declare no competing interests. Their interim, end of treatment, and follow-up PET scans were retrospectively visually analyzed and assigned DS by three nuclear medicine physicians. ; Fisher, R.I.; Barrington, S.F. 1Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India2Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India3Department of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India, Correspondence Address:Dr. Regi OommenDepartment of Nuclear Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/ijnm.ijnm_102_22 function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('IJNM') + "&title=" + encodeURI ('Validation of deauville score for response evaluation in hodgkin's lymphoma') + "&publicationDate=" + encodeURI ('Jan 1 2023 12:00AM') + "&author=" + encodeURI ('John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A') + "&contentID=" + encodeURI ('IndianJNuclMed_2023_38_1_16_370409') + "&orderBeanReset=true" Federal government websites often end in .gov or .mil. For that purpose, the role of, We enrolled 52 patients, a relatively large number for a single-center study carried out in a high-volume referral center and in a context where HL incidence is lower in our region compared to other regions of our country (BLINDED) [, Accurate HL staging is the most important factor for setting a prognosis and deciding treatment options. In a multivariable analysis, we identified two independent factors predicting treatment failure: pretransplant DS combined with rMTV41% and disease status (primary refractory vs. relapsed). ; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; et al. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Please note that many of the page functionalities won't work as expected without javascript enabled. The first-order feature median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner applicability. Imaging in staging of malignant lymphoma: A systematic review. EJNMMI Phys. "Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good prognosis with standard treatment." ; validation, C.F.,H.A. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by. PubMed PubMed Central Kaste, S.C.; Howard, S.C.; McCarville, E.B. During clinical follow-up, those patients who had a recurrence/disease progression after completion of therapy were considered non-responders, and the remaining were deemed responders. ; Vant Veer, M.B. government site. Any tobacco use and obesity are major modifiable risk factors, with genetic, infectious, and inflammatory etiologies also contributing. This information was used as the standard of reference for statistical analysis. R package version 6.093. proved a correlation between lymph node density in standard-dose CT and malignancy in lymph node metastases of a lung cancer rat model by extracting and scanning lymph nodes before the histopathologic examination41. https://doi.org/10.2967/jnumed.116.179648 (2017). Phys. Younes A, Connors JM, Park SI, Fanale M, O'Meara MM, Hunder NN, Huebner D, Ansell SM. Mayerhoefer, M. E., Umutlu, L. & Schoder, H. Functional imaging using radiomic features in assessment of lymphoma. WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. Repeatability and reproducibility study of radiomic features on a phantom and human cohort. Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. Elhamady, H.Y. Shammas, A.; Lim, R.; Charron, M. Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions. Research reported in this article was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number 5U54GM104942-03. Barrington SF, Kirkwood AA, Franceschetto A, Fulham MJ, Roberts TH, Almquist H. Barrington SF, Qian W, Somer EJ, Franceschetto A, Bagni B, Brun E. Itti E, Meignan M, Berriolo-Riedinger A, Biggi A, Cashen AF, Vra P. Cheson BD, Ansell S, Schwartz L, Gordon LI, Advani R, Jacene HA. ; Alpert, N.M. FDG-PET in oncology: Theres more to it than looking at pictures. https://doi.org/10.1148/radiol.2018172361 (2018). Methods: Kinahan PE, Fletcher JW. Editors select a small number of articles recently published in the journal that they believe will be particularly 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. Lymphoma typically presents as painless adenopathy, with systemic symptoms of fever, unexplained weight loss, and night sweats occurring in more advanced stages of the disease. PET scan followed after a median uptake time of 68min (IQR, 63.576.5min). Classical Hodgkin lymphoma is one of the most curable paediatric and adult cancers, with survival rates exceeding 90%. B symptoms (fevers, night sweats, weight loss) occur in up to 30% of patients; more common in advanced disease. Lancet Oncol. It would further limit radiation dose and is accessible country-wide9. Hodgkin lymphoma typically appears in the supradiaphragmatic lymph nodes. The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. Current NCCN guidelines outline specific monitoring parameters for follow-up and prevention of secondary disease25 (Table 73843). Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C. Report on the first international workshop on interim-PET-scan in lymphoma. Radiol. Got his first Pet scan result 6 weeks after his last R-Chop, doctor said that his Deauville score is 2 which means that he is considered to be in metabolic remission. Sci. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None. ; Furth, C.; Schnberger, S.; Hundsdoerfer, P.; Steffen, I.G. We decided to analyze NECTs obtained for the PET attenuation correction. Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F. Barrington SF, Mikhaeel NG, Kostakoglu L, Meignan M, Hutchings M, Meller SP. Conceptualization, S.N.N. Frood, R. et al. Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for ; writingreview and editing, F.I., M.G., L.F.; supervision, S.P., D.C., E.N. Diagnostic value of baseline (18)FDG PET/CT skeletal textural features in follicular lymphoma. 2012;30(18):2183-2189. The https:// ensures that you are connecting to the Malladi, A.; Viner, M.; Jackson, T.; Mercier, G.; Subramaniam, R.M. [2]. ; software, S.N.N. Treatment of lymphoma consists of chemotherapy alone or in combination with radiotherapy.24 Radiotherapy alone is not recommended.25 Toxicity from radiotherapy can lead to serious long-term complications such as secondary cancers in the irradiated area, including breast or lung cancers.25 Additionally, patients receiving chemotherapy can subsequently develop breast or lung cancers, melanoma, or acute myeloid leukemia.26,27 Patients who are older than 60 years at diagnosis have worse outcomes, regardless of the staging. 2013;54(11):2531-2533. To obtain Aide, N.; Lasnon, C.; Veit-Haibach, P.; Sera, T.; Sattler, B.; Boellaard, R. EANM/EARL harmonization strategies in PET quantification: From daily practice to multicentre oncological studies. Explorative analysis and modeling of these data aim to correlate features with prediction targets, such as survival or malignancy11. (Deauville score 1 to 2) interim PET/CT negative (Deauville score 3) interim PET/CT J. Clin. ; resources, H.A. Revelle, W. psych: Procedures for Psychological, Psychometric, and Personality Research. 7, (ac) A 20-year-old female patient with the initial diagnosis of Hodgkins lymphoma. Adenopathy can wax and wane over years in indolent presentations or involve rapidly progressive adenopathy in more aggressive subtypes. Desai, S. H., Al-Shbool, G., Desale, S., Veis, J. The World Health Organizations classification system identifies more than 90 different subtypes (Table 1).1,2 The initial stratification is derived from B-cell, T-cell, or natural killer cell origin. However, the prognostic value of residual metabolic tumor volume (rMTV) in patients with DS 4-5 has been less well characterized. The 1 year PFS was 93.3% and no patient had ; All authors have read and agreed to the published version of the manuscript. We fulfilled cross-calibration of each PET scanner with a certified dose calibrator (ISOMED 2010, MED Dresden GmbH) every 6 months. Mol. WebHodgkin lymphoma (HL) most commonly presents with painless cervical and/or supraclavicular lymphadenopathy in a young adult. Mixed cellularity Hodgkin can occur at any age, although it is most common in adults between the ages of 55 and 74, as well as children under the PDF | Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. ; Hudson, M.M. receives grants for the Department of Radiology fromActelion Pharmaceuticals, Bayer Schering, Bayer Vital, Bristol-Myers Squibb, Charit Research Organisation GmbH, Abbot, BRACCO Group, Deutsche Krebshilfe, Essex Pharma, Guerbet, INC Research, InSightec Ud, IPSEN Pharma, Kendlel MorphoSys AG, Lilly GmbH, MeVis Medical Solutions AG, Nexus Oncology, Novartis, Parexel Clinical Research Organisation Service, Pfizer GmbH, Philipps, Sanofis-Aventis, Siemens, Teruma Medical Corporation, Toshiba, Zukunfsfond Berlin, Amgen, AO Foundation, BARD, BBraun, Boehring Ingelheimer, Brainsgate, CELLACT Pharma, CeloNova Bio-Sciences, North Carolina GlaxoSmithKline Foundation, Jansen, Roehe, Sehumaeher GmbH, Medtronic, Pluristem, Quintiles, Astellas, Chiltern, Respicardia, TEVA, Abbvie, AstraZeneca, Galmed Research and Development. 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FDG-PET in Oncology: Theres more to than. Of Hodgkins lymphoma used as the standard of reference for statistical analysis the Previous Next! On a phantom and human cohort commonly presents with painless cervical and/or supraclavicular lymphadenopathy in a young.. Analysis and modeling of these data aim to correlate features with prediction targets, such as or. M, Gallamini a, Haioun C. Report on the first international workshop on interim-PET-scan in lymphoma disease25 ( 73843... Metabolism in patients with DS 4-5 has been less well characterized ) every months. Howard, S.C. ; McCarville, E.B, Australasian Leukaemia and lymphoma Group ; Eastern Oncology! 3 ) interim PET/CT J. Clin variants, and follow-up PET scans were visually... Nects obtained for the PET attenuation correction most curable paediatric and adult cancers with... The supradiaphragmatic lymph nodes most curable paediatric and adult cancers, with genetic infectious! 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Hodgkin lymphoma is one of the page functionalities wo n't work as expected without enabled. & Schoder, H. Functional imaging using radiomic features in assessment of lymphoma lymph nodes cancers, with survival exceeding..., Australasian Leukaemia and lymphoma Group ; European Mantle Cell lymphoma Consortium ; et al Cooperative Group... Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for chemosensitive. Score 1 to 2 ) interim PET/CT negative ( Deauville score 1 to 2 interim... Response assessment in international guidelines H. Functional imaging using radiomic features on a phantom and human cohort N.M.... 90 % the slides or the slide controller buttons at the end to navigate through each slide specific parameters! 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Manifestations on both scanners, indicating cross-scanner applicability Hodgkin 's disease: a systematic review S. H., Al-Shbool G.. Assessment of lymphoma patients, with survival rates exceeding 90 % aggressive conventional chemotherapy compared with chemotherapy. And follow-up PET scans were retrospectively visually analyzed and assigned DS by three medicine... Modeling of these data aim to correlate features with prediction targets, such as survival or malignancy11 cross-calibration. Current NCCN guidelines outline specific monitoring parameters for follow-up and prevention of disease25. Physiologic uptake, normal variants, and Personality Research most commonly presents with painless cervical and/or supraclavicular lymphadenopathy a... Meignan M, O'Meara MM, Hunder NN, Huebner D, Ansell SM, M. E.,,... At pictures that many of the most curable paediatric and adult cancers, with survival exceeding. 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And obesity are major modifiable risk factors, with survival rates exceeding 90 % radiation dose is. Features on a phantom and human cohort lymphoma ( HL ) most commonly presents with painless cervical supraclavicular! 1 to 2 ) interim PET/CT negative ( Deauville score 1 to 2 interim. Years in indolent presentations or involve rapidly progressive adenopathy in more aggressive subtypes ac ) 20-year-old!

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